Progression of motor axon dysfunction and ectopic Nav1.8 expression in a mouse model of Charcot-Marie-Tooth disease 1B

Progression of motor axon dysfunction and ectopic Nav1.8 expression in a mouse model of Charcot-Marie-Tooth disease 1B

Mice heterozygously deficient for the myelin protein P0 gene (P0+/−) develop a slowly progressing neuropathy modeling demyelinating Charcot-Marie-Tooth disease (CMT1B). The aim of the study was to investigate the long-term progression of motor dysfunction in P0+/− mice at 3, 7, 12 and 20 months. By...

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Bibliographic Details
Main Authors: Mette R. Rosberg, Susana Alvarez, Dennis Klein, Finn Cilius Nielsen, Rudolf Martini, S. Rock Levinson, Christian Krarup, Mihai Moldovan
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neurobiology of Disease
Subjects:
Nerve activity
Ion channels
Excitability
Node of Ranvier
Internode
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301085

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http://www.sciencedirect.com/science/article/pii/S0969996116301085

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