De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

Summary: CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of...

Full description

Bibliographic Details
Main Authors: Masaki Yagi, Mio Kabata, Tomoyo Ukai, Sho Ohta, Akito Tanaka, Yui Shimada, Michihiko Sugimoto, Kimi Araki, Keisuke Okita, Knut Woltjen, Konrad Hochedlinger, Takuya Yamamoto, Yasuhiro Yamada
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119301304

Internet

http://www.sciencedirect.com/science/article/pii/S2213671119301304

Similar Items