Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

Measures of lung function are heritable, and thus, we sought to utilise genetics to propose drug-repurposing candidates that could improve respiratory outcomes. Lung function measures were found to be genetically correlated with seven druggable biochemical traits, with further evidence of a causal r...

Full description

Bibliographic Details
Main Authors: William R Reay, Sahar I El Shair, Michael P Geaghan, Carlos Riveros, Elizabeth G Holliday, Mark A McEvoy, Stephen Hancock, Roseanne Peel, Rodney J Scott, John R Attia, Murray J Cairns
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
GWAS
causal inference
TWAS
drug repurposing
lung function
polygenic scoring
Online Access:https://elifesciences.org/articles/63115

Internet

https://elifesciences.org/articles/63115

Similar Items