Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice

Abstract The current study evaluated the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice. Phenotypic modifications of irradiated, Hey2 siRNA- and Hey2 vector plasmid-transfected human umbi...

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Bibliographic Details
Main Authors: Elodie Mintet, Jérémy Lavigne, Vincent Paget, Georges Tarlet, Valérie Buard, Olivier Guipaud, Jean-Christophe Sabourin, Maria-Luisa Iruela-Arispe, Fabien Milliat, Agnès François
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05389-8

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https://doi.org/10.1038/s41598-017-05389-8

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