High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.

High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.

BACKGROUND: Inactivation of the p53 pathway that controls cell cycle progression, apoptosis and senescence, has been proposed to occur in virtually all human tumors and p53 is the protein most frequently mutated in human cancer. However, the mutational status of p53 in melanoma is still controversia...

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Main Authors: Roland Houben, Sonja Hesbacher, Corinna P Schmid, Claudia S Kauczok, Ulrike Flohr, Sebastian Haferkamp, Cornelia S L Müller, David Schrama, Jörg Wischhusen, Jürgen C Becker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3132323?pdf=render

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http://europepmc.org/articles/PMC3132323?pdf=render

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