Anesthesia and Surgery Impair Blood–Brain Barrier and Cognitive Function in Mice

Anesthesia and Surgery Impair Blood–Brain Barrier and Cognitive Function in Mice

Blood–brain barrier (BBB) dysfunction, e.g., increase in BBB permeability, has been reported to contribute to cognitive impairment. However, the effects of anesthesia and surgery on BBB permeability, the underlying mechanisms, and associated cognitive function remain largely to be determined. Here,...

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Bibliographic Details
Main Authors: Siming Yang, Changping Gu, Emiri T. Mandeville, Yuanlin Dong, Elga Esposito, Yiying Zhang, Guang Yang, Yuan Shen, Xiaobing Fu, Eng H. Lo, Zhongcong Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
anesthesia/surgery
interleukin-6
blood–brain barrier
age
cognition
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00902/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00902/full

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