Further Characterization of the Capsule-Like Complex (CLC) Produced by Francisella tularensis Subspecies tularensis: Protective Efficacy and Similarity to Outer Membrane Vesicles

Further Characterization of the Capsule-Like Complex (CLC) Produced by Francisella tularensis Subspecies tularensis: Protective Efficacy and Similarity to Outer Membrane Vesicles

Francisella tularensis is the etiologic agent of tularemia, and subspecies tularensis (type A) is the most virulent subspecies. The live vaccine strain (LVS) of subspecies holarctica produces a capsule-like complex (CLC) that consists of a large variety of glycoproteins. Expression of the CLC is gre...

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Bibliographic Details
Main Authors: Anna E. Champion, Aloka B. Bandara, Nrusingh Mohapatra, Kelly M. Fulton, Susan M. Twine, Thomas J. Inzana
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Francisella tularensis
virulence factors
capsule-like complex
outer membrane vesicles
protection
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00182/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00182/full

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