CD99–PTPN12 Axis Suppresses Actin Cytoskeleton-Mediated Dimerization of Epidermal Growth Factor Receptor

CD99–PTPN12 Axis Suppresses Actin Cytoskeleton-Mediated Dimerization of Epidermal Growth Factor Receptor

The epidermal growth factor receptor (EGFR), a member of ErbB receptor tyrosine kinase (RTK) family, is activated through growth factor-induced reorganization of the actin cytoskeleton and subsequent dimerization. We herein explored the molecular mechanism underlying the suppression of ligand-induce...

Full description

Bibliographic Details
Main Authors: Kyoung-Jin Lee, Yuri Kim, Min Seo Kim, Hyun-Mi Ju, Boyoung Choi, Hansoo Lee, Dooil Jeoung, Ki-Won Moon, Dongmin Kang, Jiwon Choi, Jong In Yook, Jang-Hee Hahn
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
actin cytoskeletal reorganization
breast cancer
CD99 agonist
EGFR dimerization
endocytosis
FAK dephosphorylation
Online Access:https://www.mdpi.com/2072-6694/12/10/2895

Internet

https://www.mdpi.com/2072-6694/12/10/2895

Similar Items