Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases

Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases

Abstract Motor-, behavior- and/or cognition-related symptoms are key hallmarks in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with TDP-43 pathology (FTLD-TDP), respectively. It has been reported that these patients also experience sleep disturbances...

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Bibliographic Details
Main Authors: Lieselot Dedeene, Evelien Van Schoor, Rik Vandenberghe, Philip Van Damme, Koen Poesen, Dietmar Rudolf Thal
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Frontotemporal dementia
C9orf72
Dipeptide repeat proteins
TDP-43
Pineal gland
Online Access:https://doi.org/10.1186/s40478-019-0845-9

Internet

https://doi.org/10.1186/s40478-019-0845-9

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