Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection

Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) has a continuing impact on residents and travelers in underdeveloped countries. Both heat-labile (LT) and heat-stable (ST) enterotoxins contribute to pathophysiology via induction of cyclic nucleotide synthesis, and previous investigations f...

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Bibliographic Details
Main Authors: Jennifer Foulke-Abel, Huimin Yu, Laxmi Sunuwar, Ruxian Lin, James M. Fleckenstein, James B. Kaper, Mark Donowitz
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Gut Microbes
Subjects:
e. coli heat-stable enterotoxin
e. coli heat-labile enterotoxin
cyclic nucleotide
etec
pde5
mrp5
enteroid monolayer
intestinal organoid
host–pathogen interaction
Online Access:http://dx.doi.org/10.1080/19490976.2020.1752125

Internet

http://dx.doi.org/10.1080/19490976.2020.1752125

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