Evidence of Different IL-1β Activation Pathways in Innate Immune Cells From Indeterminate and Cardiac Patients With Chronic Chagas Disease

Evidence of Different IL-1β Activation Pathways in Innate Immune Cells From Indeterminate and Cardiac Patients With Chronic Chagas Disease

Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convert...

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Main Authors: Nayara I. Medeiros, Bruna F. Pinto, Silvana M. Elói-Santos, Andréa Teixeira-Carvalho, Luísa M. D. Magalhães, Walderez O. Dutra, Rodrigo Correa-Oliveira, Juliana A. S. Gomes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
IL-1β activation pathways
caspase-1-independent
gelatinases
Chagas disease
chagasic cardiomyopathy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00800/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00800/full

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