Glucosamine-Induced Autophagy through AMPK–mTOR Pathway Attenuates Lipofuscin-Like Autofluorescence in Human Retinal Pigment Epithelial Cells In Vitro

Glucosamine-Induced Autophagy through AMPK–mTOR Pathway Attenuates Lipofuscin-Like Autofluorescence in Human Retinal Pigment Epithelial Cells In Vitro

Age-related macular degeneration (AMD) is a vision-threatening age-associated disease. The retinal pigment epithelial (RPE) cells phagocytose and digest photoreceptor outer segment (POS). Incomplete digestion of POS leads to lipofuscin accumulation, which contributes to the pathology of the AMD. Aut...

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Bibliographic Details
Main Authors: Ching-Long Chen, Yi-Hao Chen, Chang-Min Liang, Ming-Cheng Tai, Da-Wen Lu, Jiann-Torng Chen
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
glucosamine
autophagy
lipofuscin
retinal pigment epithelial cells
Online Access:http://www.mdpi.com/1422-0067/19/5/1416

Internet

http://www.mdpi.com/1422-0067/19/5/1416

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