Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD

Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive fat deposits in hepatocytes without excessive alcohol intake. NAFLD is influenced by genetic factors, and the heritability has been estimated at 0.35 to 0.6 by twin studies. We explored rare varian...

Full description

Bibliographic Details
Main Authors: Supichaya Boonvisut, Ken Yoshida, Kazuhiro Nakayama, Kazuhisa Watanabe, Hiroshi Miyashita, Sadahiko Iwamoto
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Lipids in Health and Disease
Subjects:
Non-alcoholic fatty liver disease
Rare variants
Re-sequencing
Association study
Online Access:http://link.springer.com/article/10.1186/s12944-017-0570-y

Internet

http://link.springer.com/article/10.1186/s12944-017-0570-y

Similar Items