AT1R/GSK-3β/mTOR Signaling Pathway Involved in Angiotensin II-Induced Neuronal Apoptosis after HIE Both In Vitro and In Vivo

AT1R/GSK-3β/mTOR Signaling Pathway Involved in Angiotensin II-Induced Neuronal Apoptosis after HIE Both In Vitro and In Vivo

Objective. The focus of the present study is to evaluate the effects of Angiotensin II (Ang II) on neuronal apoptosis after HIE and the potential underlying mechanisms. Methods. Primary neonatal rat cortical neurons were used to study the oxygen-glucose deprivation (OGD) cell model. The expressions...

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Bibliographic Details
Main Authors: Wei Si, Banghui Li, Cameron Lenahan, Shirong Li, Ran Gu, Hao Qu, Lu Wang, Jiapeng Liu, Tian Tian, Qian Wang, null XikeWang, Xiao Hu, Gang Zuo
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/8864323

Internet

http://dx.doi.org/10.1155/2020/8864323

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