Reducing the Oxidation Level of Dextran Aldehyde in a Chitosan/Dextran-Based Surgical Hydrogel Increases Biocompatibility and Decreases Antimicrobial Efficacy

Reducing the Oxidation Level of Dextran Aldehyde in a Chitosan/Dextran-Based Surgical Hydrogel Increases Biocompatibility and Decreases Antimicrobial Efficacy

A highly oxidized form of a chitosan/dextran-based hydrogel (CD-100) containing 80% oxidized dextran aldehyde (DA-100) was developed as a post-operative aid, and found to significantly prevent adhesion formation in endoscopic sinus surgery (ESS). However, the CD-100 hydrogel showed moderate in vitro...

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Bibliographic Details
Main Authors: Maggie Chan, Heather J. L. Brooks, Stephen C. Moratti, Lyall R. Hanton, Jaydee D. Cabral
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:International Journal of Molecular Sciences
Subjects:
hydrogel
biocompatibility
chitosan
oxidized dextran
antimicrobial
Online Access:http://www.mdpi.com/1422-0067/16/6/13798

Internet

http://www.mdpi.com/1422-0067/16/6/13798

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