ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

The Hypoxia-inducible Factor (HIF) family of transcriptional regulators coordinates the expression of dozens of genes in response to oxygen deprivation. Mammalian development occurs in a hypoxic environment and HIF-null mice therefore die in utero due to multiple embryonic and placental defects. Mou...

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Bibliographic Details
Main Authors: Hwa J Choi, Timothy A Sanders, Kathryn V Tormos, Kurosh Ameri, Justin D Tsai, Angela M Park, Julissa Gonzalez, Anthony M Rajah, Xiaowei Liu, Diana M Quinonez, Paolo F Rinaudo, Emin Maltepe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3578927?pdf=render

Internet

http://europepmc.org/articles/PMC3578927?pdf=render

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