PRMT5 regulates ovarian follicle development by facilitating Wt1 translation

PRMT5 regulates ovarian follicle development by facilitating Wt1 translation

Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric dimethylation of arginine. Here, we found that PRMT5 was expressed at high level in ovarian granulosa cells of growing follicles. Inactivation of Prmt5 in granulosa cells resulted in aberrant follicle...

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Bibliographic Details
Main Authors: Min Chen, Fangfang Dong, Zhiming Shen, Haowei Wu, Changhuo Cen, Xiuhong Cui, Shilai Bao, Fei Gao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
PRMT5
ovary
granulosa cells
Wt1
IRES
Online Access:https://elifesciences.org/articles/68930

Internet

https://elifesciences.org/articles/68930

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