Molecular Interactions of the Polysialytransferase Domain (PSTD) in ST8Sia IV with CMP-Sialic Acid and Polysialic Acid Required for Polysialylation of the Neural Cell Adhesion Molecule Proteins: An NMR Study

Molecular Interactions of the Polysialytransferase Domain (PSTD) in ST8Sia IV with CMP-Sialic Acid and Polysialic Acid Required for Polysialylation of the Neural Cell Adhesion Molecule Proteins: An NMR Study

Polysialic acid (polySia) is an unusual glycan that posttranslational modifies neural cell adhesion molecule (NCAM) proteins in mammalian cells. The up-regulated expression of polySia-NCAM is associated with tumor progression in many metastatic human cancers and in neurocognitive processes. Two memb...

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Bibliographic Details
Main Authors: Si-Ming Liao, Bo Lu, Xue-Hui Liu, Zhi-Long Lu, Shi-Jie Liang, Dong Chen, Frederic A. Troy, Ri-Bo Huang, Guo-Ping Zhou
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
nmr
sialic acid (sia)
polysialic acid (polysia)
polysialyltransferases
st8sia ii (stx), st8sia iv (pst)
neural cell adhesion molecule proteins (ncams)
pstd
pbr
degree of polymerization (dp)
chemical shift perturbation (csp)
Online Access:https://www.mdpi.com/1422-0067/21/5/1590

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https://www.mdpi.com/1422-0067/21/5/1590

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