Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro

Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro

Emicizumab is a humanized bispecific antibody that binds simultaneously to factor (F) IXa and FX replacing the cofactor function of FVIIIa. Because emicizumab recognizes FIX/FIXa and FX/FXa, a question may arise whether emicizumab competes with antithrombin (AT) and/or tissue factor pathway inhibito...

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Bibliographic Details
Main Authors: Mariko Noguchi-Sasaki, Tetsuhiro Soeda, Atsunori Ueyama, Atsushi Muto, Michinori Hirata, Hidetomo Kitamura, Kaori Fujimoto-Ouchi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, Takehisa Kitazawa
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-01-01
Series:TH Open
Subjects:
emicizumab
antithrombin
tfpi
coagulation factors
hemophilia a
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1636538

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1636538

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