Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian and complex disease. A strong founder effect, severe isolation, and substantial inbreeding have dramatically r...

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Bibliographic Details
Main Authors: Jennifer K Lowe, Julian B Maller, Itsik Pe'er, Benjamin M Neale, Jacqueline Salit, Eimear E Kenny, Jessica L Shea, Ralph Burkhardt, J Gustav Smith, Weizhen Ji, Martha Noel, Jia Nee Foo, Maude L Blundell, Vita Skilling, Laura Garcia, Marcia L Sullivan, Heather E Lee, Anna Labek, Hope Ferdowsian, Steven B Auerbach, Richard P Lifton, Christopher Newton-Cheh, Jan L Breslow, Markus Stoffel, Mark J Daly, David M Altshuler, Jeffrey M Friedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2628735?pdf=render

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http://europepmc.org/articles/PMC2628735?pdf=render

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