MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury

MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury

Abstract Background Neonatal hypoxic-ischemic (HI) brain injury is a leading cause of acute mortality and chronic disability in newborns. Our previous studies demonstrated that HI insult significantly increased microRNA-210 (miR-210) in the brain of rat pups and inhibition of brain endogenous miR-21...

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Bibliographic Details
Main Authors: Qingyi Ma, Chiranjib Dasgupta, Guofang Shen, Yong Li, Lubo Zhang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Neonatal hypoxia-ischemia
MicroRNA-210
The ten eleven translocation (TET) methylcytosine dioxygenase 2
Acetyl-p65
Pro-inflammatory cytokines
BV2 mouse microglia cell line
Online Access:https://doi.org/10.1186/s12974-020-02068-w

Internet

https://doi.org/10.1186/s12974-020-02068-w

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