Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogues of mexiletine

Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogues of mexiletine

We previously showed that the β-adrenoceptor modulators, clenbuterol and propranolol, directly blocked voltage-gated sodium channels, whereas salbutamol and nadolol did not (Desaphy et al., 2003), suggesting the presence of two hydroxyl groups on the aromatic moiety of the drugs as a molecular requi...

Full description

Bibliographic Details
Main Authors: Jean-François eDesaphy, Antonella eDipalma, Teresa eCostanza, Roberta eCarbonara, Maria Maddalena eDinardo, Alessia eCatalano, Alessia eCarocci, Giovanni eLentini, Carlo eFranchini, Diana eConte Camerino
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Pharmacology
Subjects:
Sodium channel
hNav1.4
local anesthetic receptor
mexiletine analogues
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00017/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00017/full

Similar Items