Reactivation of Intestinal Inflammation Is Suppressed by Catestatin in a Murine Model of Colitis via M1 Macrophages and Not the Gut Microbiota

Reactivation of Intestinal Inflammation Is Suppressed by Catestatin in a Murine Model of Colitis via M1 Macrophages and Not the Gut Microbiota

While there is growing awareness of a relationship between chromogranin-A (CHGA) and susceptibility to inflammatory conditions, the role of human catestatin [(hCTS); CHGA352–67] in the natural history of established inflammatory bowel disease is not known. Recently, using two different experimental...

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Bibliographic Details
Main Authors: Mohammad F. Rabbi, Nour Eissa, Peris M. Munyaka, Laëtitia Kermarrec, Omar Elgazzar, Ehsan Khafipour, Charles N. Bernstein, Jean Eric Ghia
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
chromogranin-A
catestatin
gut inflammation
M1 and M2 macrophage
gut dysbiosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00985/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00985/full

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