A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects

A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects

Mitochondria continually move, fuse and divide, and these dynamics are essential for the proper function of the organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs as well as preserving the...

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Bibliographic Details
Main Authors: Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin
Format: Article
Language:English
Published: The Company of Biologists 2019-02-01
Series:Disease Models & Mechanisms
Subjects:
Mitochondrial fusion
Mitochondrial DNA
Hexestrol
Clomifene
Yeast
OPA1
Online Access:http://dmm.biologists.org/content/12/2/dmm036558

Internet

http://dmm.biologists.org/content/12/2/dmm036558

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