Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy

Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy

Abstract Background Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis. However, the underlying mechanism by which COPS3 promotes metastasis of osteosarcoma and its role in autophagy...

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Bibliographic Details
Main Authors: Fan Zhang, Taiqiang Yan, Wei Guo, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Bingxin Zheng, Hongliang Zhang, Tingting Ren
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
COPS3
Raf-1
Beclin1
Autophagy
Osteosarcoma metastasis
Online Access:http://link.springer.com/article/10.1186/s13046-018-0791-6

Internet

http://link.springer.com/article/10.1186/s13046-018-0791-6

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