Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes.

Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes.

The objective was to examine the protective effect of metformin (Met) on myocardial ischemia-reperfusion (IR) injury and whether the mechanism was related to the AMPK/ antioxidant enzymes signaling pathway. Rat Langendorff test and H2O2-treated rat cardiomyocytes (H9c2) were used in this study. Met...

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Bibliographic Details
Main Authors: Xiaoling Wang, Lei Yang, Licheng Kang, Jing Li, Liang Yang, Jincai Zhang, Jie Liu, Mengmeng Zhu, Qiong Zhang, Yanna Shen, Zhi Qi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5560646?pdf=render

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http://europepmc.org/articles/PMC5560646?pdf=render

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