The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. S...

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Main Authors:	Courtney Lane-Donovan, Joachim Herz
Format:	Article
Language:	English
Published:	Elsevier 2017-06-01
Series:	Journal of Lipid Research
Subjects:	apolipoproteins Alzheimer's disease endocytosis lipoprotein receptors cell signaling neurons
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520309974

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spelling	doaj-1732b6ee4cba4014b7cfb23f441854c02021-04-29T04:34:38ZengElsevierJournal of Lipid Research0022-22752017-06-0158610361043The ApoE receptors Vldlr and Apoer2 in central nervous system function and diseaseCourtney Lane-Donovan0Joachim Herz1Departments of Molecular Genetics and Neuroscience and Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390To whom correspondence should be addressed.; Departments of Molecular Genetics and Neuroscience and Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease.http://www.sciencedirect.com/science/article/pii/S0022227520309974apolipoproteinsAlzheimer's diseaseendocytosislipoprotein receptorscell signalingneurons
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Courtney Lane-Donovan Joachim Herz
spellingShingle	Courtney Lane-Donovan Joachim Herz The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease Journal of Lipid Research apolipoproteins Alzheimer's disease endocytosis lipoprotein receptors cell signaling neurons
author_facet	Courtney Lane-Donovan Joachim Herz
author_sort	Courtney Lane-Donovan
title	The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
title_short	The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
title_full	The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
title_fullStr	The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
title_full_unstemmed	The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
title_sort	apoe receptors vldlr and apoer2 in central nervous system function and disease
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	2017-06-01
description	The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease.
topic	apolipoproteins Alzheimer's disease endocytosis lipoprotein receptors cell signaling neurons
url	http://www.sciencedirect.com/science/article/pii/S0022227520309974
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The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

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