Identification of VDR Antagonists among Nuclear Receptor Ligands Using Virtual Screening

Identification of VDR Antagonists among Nuclear Receptor Ligands Using Virtual Screening

Herein, we described the development of two virtual screens to identify new vitamin D receptor (VDR) antagonists among nuclear receptor (NR) ligands. Therefore, a database of 14330 nuclear receptor ligands and their NR affinities was assembled using the online available “Binding Database.” Two diffe...

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Bibliographic Details
Main Authors: Kelly Teske, Premchendar Nandhikonda, Jonathan W. Bogart, Belaynesh Feleke, Preetpal Sidhu, Nina Y. Yuan, Joshua Preston, Robin Goy, Lanlan Han, Nicholas R. Silvaggi, Rakesh K. Singh, Daniel D. Bikle, James M. Cook, Leggy A. Arnold
Format: Article
Language:English
Published: KenzPub 2014-04-01
Series:Nuclear Receptor Research
Subjects:
Virtual screening
nuclear receptor
vitamin D receptor
thyroid receptor
estrogen receptor
Online Access:http://www.kenzpub.com/journals/nurr/2014/101076/

Internet

http://www.kenzpub.com/journals/nurr/2014/101076/

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