Molecular characterization of breast and lung tumors by integration of multiple data types with functional sparse-factor analysis.

Effective cancer treatment is crucially dependent on the identification of the biological processes that drive a tumor. However, multiple processes may be active simultaneously in a tumor. Clustering is inherently unsuitable to this task as it assigns a tumor to a single cluster. In addition, the wi...

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Bibliographic Details
Main Authors: Tycho Bismeijer, Sander Canisius, Lodewyk F A Wessels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006520