Metabolic Effects of Hypoxia in Colorectal Cancer by 13C NMR Isotopomer Analysis

13C NMR isotopomer analysis was used to characterize intermediary metabolism in three colorectal cancer cell lines (WiDr, LS1034, and C2BBe1) and determine the “metabolic remodeling” that occurs under hypoxia. Under normoxia, the three colorectal cancer cell lines present high rates of lactate produ...

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Bibliographic Details
Main Authors: Ana M. Abrantes, Ludgero C. Tavares, Salomé Pires, João Casalta-Lopes, Cândida Mendes, Marta Simões, Manuela M. Grazina, Rui A. Carvalho, Maria Filomena Botelho
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/759791