Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

The live attenuated yellow fever virus (YFV) vaccine 17D stands as a “gold standard” for a successful vaccine. 17D was developed empirically by passaging the wild-type Asibi strain in mouse and chicken embryo tissues. Despite its immense success, the molecular determinants for virulence attenuation...

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Bibliographic Details
Main Authors: Maria Dolores Fernandez-Garcia, Laurent Meertens, Maxime Chazal, Mohamed Lamine Hafirassou, Ophélie Dejarnac, Alessia Zamborlini, Philippe Despres, Nathalie Sauvonnet, Fernando Arenzana-Seisdedos, Nolwenn Jouvenet, Ali Amara
Format: Article
Language:English
Published: American Society for Microbiology 2016-02-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/1/e01956-15

Internet

http://mbio.asm.org/cgi/content/full/7/1/e01956-15

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