Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies

Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies

Parkinson disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy neurites. Ubiquitin C-terminal hydrolase-1 (UCHL-1) disassembles polyubiquitin chains to increase the availabil...

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Bibliographic Details
Main Authors: Marta Barrachina, Esther Castaño, Esther Dalfó, Tamara Maes, Carlos Buesa, Isidro Ferrer
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Neurobiology of Disease
Subjects:
Dementia with Lewy Bodies
Parkinson's disease
UCHL
Proteasome
α-synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105003086

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http://www.sciencedirect.com/science/article/pii/S0969996105003086

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