Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy neurites. Ubiquitin C-terminal hydrolase-1 (UCHL-1) disassembles polyubiquitin chains to increase the availabil...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2006-05-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996105003086 |