Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

Tau hyperphosphorylation has been implicated in the pathogenesis of a variety of forms of human epilepsy. Here we investigated whether treatment with sodium selenate, a drug which reduces pathological hyperphosphorylated tau by enhancement of PP2A activity, would inhibit seizures in rodent models. I...

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Bibliographic Details
Main Authors: Nigel C. Jones, Thanh Nguyen, Niall M. Corcoran, Dennis Velakoulis, Tracy Chen, Robert Grundy, Terence J. O'Brien, Christopher M. Hovens
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Sodium selenate
Hyperphosphorylated tau
Seizure
Epilepsy models
Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003809

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http://www.sciencedirect.com/science/article/pii/S0969996111003809

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