Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue

Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue

Background and PurposeThe exact mechanism of spontaneous pacemaking is not fully understood. Recent results suggest tight cooperation between intracellular Ca2+ handling and sarcolemmal ion channels. An important player of this crosstalk is the Na+/Ca2+ exchanger (NCX), however, direct pharmacologic...

Full description

Bibliographic Details
Main Authors: Zsófia Kohajda, Noémi Tóth, Jozefina Szlovák, Axel Loewe, Gergő Bitay, Péter Gazdag, János Prorok, Norbert Jost, Jouko Levijoki, Piero Pollesello, Julius Gy. Papp, András Varró, Norbert Nagy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
Na+/Ca2+ exchanger
funny-current
ORM-10962
pacemaking
sinus-node
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01632/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01632/full

Similar Items