Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.

Bibliographic Details
Main Authors: Muhammad M. Mohiuddin, Avneesh K. Singh, Philip C. Corcoran, Marvin L. Thomas III, Tannia Clark, Billeta G. Lewis, Robert F. Hoyt, Michael Eckhaus, Richard N. Pierson III, Aaron J. Belli, Eckhard Wolf, Nikolai Klymiuk, Carol Phelps, Keith A. Reimann, David Ayares, Keith A. Horvath
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11138

Internet

https://doi.org/10.1038/ncomms11138

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