Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease

Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murin...

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Bibliographic Details
Main Authors: Joana Neves, Dominik Leitz, Simone Kraut, Christina Brandenberger, Raman Agrawal, Norbert Weissmann, Christian Mühlfeld, Marcus A. Mall, Sandro Altamura, Martina U. Muckenthaler
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:EBioMedicine
Subjects:
Restrictive lung disease
Ferroportin
Hereditary hemochromatosis
Iron Overload
Hepcidin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301913

Internet

http://www.sciencedirect.com/science/article/pii/S2352396417301913

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