Using molecular mechanics to predict bulk material properties of fibronectin fibers.

The structural proteins of the extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time scales of cell traction forces. Several proteins such as fibronectin (Fn) and fibrin undergo molecular conformational changes that extend the proteins and are believed to...

Full description

Bibliographic Details
Main Authors: Mark J Bradshaw, Man C Cheung, Daniel J Ehrlich, Michael L Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3531316?pdf=render