Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

Abstract Background Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. Methods The response of breast cancer cell lines (MCF-7 and MDA-M...

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Bibliographic Details
Main Authors: Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12885-017-3953-6