Predicting effective drug combinations using gradient tree boosting based on features extracted from drug-protein heterogeneous network

Predicting effective drug combinations using gradient tree boosting based on features extracted from drug-protein heterogeneous network

Abstract Background Although targeted drugs have contributed to impressive advances in the treatment of cancer patients, their clinical benefits on tumor therapies are greatly limited due to intrinsic and acquired resistance of cancer cells against such drugs. Drug combinations synergistically inter...

Full description

Bibliographic Details
Main Authors: Hui Liu, Wenhao Zhang, Lixia Nie, Xiancheng Ding, Judong Luo, Ling Zou
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Bioinformatics
Subjects:
Drug combination
Random walk
Heterogenous network
Online Access:https://doi.org/10.1186/s12859-019-3288-1

Internet

https://doi.org/10.1186/s12859-019-3288-1

Similar Items