Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1

Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1

Electronic pacemakers still face major shortcomings that are largely intrinsic to their hardware-based design. Radical improvements can potentially be generated by gene or cell therapy-based biological pacemakers. Our previous work identified adenoviral gene transfer of Hcn2 and SkM1, encoding a “fu...

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Bibliographic Details
Main Authors: Anna M. D. Végh, Arie O. Verkerk, Lucía Cócera Ortega, Jianan Wang, Dirk Geerts, Mischa Klerk, Kirsten Lodder, Ruby Nobel, Anke J. Tijsen, Harsha D. Devalla, Vincent M. Christoffels, Max Medina-Ramírez, Anke M. Smits, Hanno L. Tan, Ronald Wilders, Marie José T. H. Goumans, Gerard J. J. Boink
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
biological pacemaker
gene therapy
cell therapy
progenitor cells
HCN channels
SkM1 channels
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.588679/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.588679/full

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