Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism <it>Dictyostelium discoideum</it>

Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism <it>Dictyostelium discoideum</it>

<p>Abstract</p> <p>Many neurodegenerative disorders, although related by their destruction of brain function, display remarkable cellular and/or regional pathogenic specificity likely due to a deregulated functionality of the mutant protein. However, neurodegenerative disease genes...

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Bibliographic Details
Main Author: Myre Michael A
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Biomedical Science
Subjects:
<it>Dictyostelium discoideum</it>
Model organism
Neurodegeneration
Huntingtin
Presenilin
γ-secretase
Hirano bodies
Neurotransmitter homologues
Online Access:http://www.jbiomedsci.com/content/19/1/41

Internet

http://www.jbiomedsci.com/content/19/1/41

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