The Conserved Arginine Cluster in the Insert of the Third Cytoplasmic Loop of the Long Form of the D2 Dopamine Receptor (D2L-R) Acts as an Intracellular Retention Signal

The Conserved Arginine Cluster in the Insert of the Third Cytoplasmic Loop of the Long Form of the D2 Dopamine Receptor (D2L-R) Acts as an Intracellular Retention Signal

This study examined whether the conserved arginine cluster present within the 29-amino acid insert of the long form of the D2 dopamine receptor (D2L-R) confers its predominant intracellular localization. We hypothesized that the conserved arginine cluster (RRR) located within the insert could act as...

Full description

Bibliographic Details
Main Authors: Valentina Kubale, Kaja Blagotinšek, Jane Nøhr, Karin A. Eidne, Milka Vrecl
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:International Journal of Molecular Sciences
Subjects:
D2 dopamine receptors
endoplasmic reticulum (ER) retention motif
confocal microscopy
surface expression
bioluminescence resonance energy transfer (BRET2)
cAMP signaling
Online Access:http://www.mdpi.com/1422-0067/17/7/1152

Internet

http://www.mdpi.com/1422-0067/17/7/1152

Similar Items