Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats

The main objective of this study was to investigate the action of doxycycline hyclate (Dx) in the skin wound healing process in Wistar rats. We investigated the effect of Dx on inflammatory cell recruitment and production of inflammatory mediators via in vitro and in vivo analysis. In addition, we a...

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Main Authors: Luciana S. Altoé, Raul S. Alves, Lyvia L. Miranda, Mariáurea M. Sarandy, Daniel S. S. Bastos, Elda Gonçalves-Santos, Rômulo D. Novaes, Reggiani V. Gonçalves
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2021/4681041