Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation

Summary: Centrosome separation in late G2/ early prophase requires precise spatial coordination that is determined by a balance of forces promoting and antagonizing separation. The major effector of centrosome separation is the kinesin Eg5. However, the identity and regulation of Eg5-antagonizing fo...

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Bibliographic Details
Main Authors: Tom Stiff, Fabio R. Echegaray-Iturra, Harry J. Pink, Alex Herbert, Constantino Carlos Reyes-Aldasoro, Helfrid Hochegger
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
Eg5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306343