Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly. However, the underlying mechanisms remain largely unknown. Here, we found that monocytes...

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Bibliographic Details
Main Authors: Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
human metabolism
Immunology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221007343

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http://www.sciencedirect.com/science/article/pii/S2589004221007343

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