Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension

Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension

Ivabradine, the selective inhibitor of the If current in the sinoatrial node, exerts cardiovascular protection by its bradycardic effect and potentially pleiotropic actions. However, there is a shortage of data regarding ivabradine’s interaction with the renin-angiotensin-aldosterone syste...

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Bibliographic Details
Main Authors: Fedor Simko, Tomas Baka, Marko Poglitsch, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Stefan Zorad, Michaela Adamcova, Ludovit Paulis
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
ivabradine
L-NAME
hypertension
fibrosis
angiotensin II
aldosterone
heart function
Online Access:http://www.mdpi.com/1422-0067/19/10/3017

Internet

http://www.mdpi.com/1422-0067/19/10/3017

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