Tonic Endocannabinoid Signaling Gates Synaptic Plasticity in Dorsal Raphe Nucleus Serotonin Neurons Through Peroxisome Proliferator-Activated Receptors

Tonic Endocannabinoid Signaling Gates Synaptic Plasticity in Dorsal Raphe Nucleus Serotonin Neurons Through Peroxisome Proliferator-Activated Receptors

Endocannabinoids (eCBs), which include 2-arachidonoylglycerol (2-AG) and anandamide (AEA) are lipid signaling molecules involved in the regulation of an array of behavioral and physiological functions. Released by postsynaptic neurons, eCBs mediate both phasic and tonic signaling at central synapses...

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Bibliographic Details
Main Authors: Saida Oubraim, Ruixiang Wang, Kathryn A Hausknecht, Roh-Yu Shen, Samir Haj-Dahmane
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
endocannabinoid
2-AG
dorsal raphe
tLTP
PPARγ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.691219/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.691219/full

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