Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

Most currently available small molecule inhibitors of DNA replication lack enzymatic specificity, resulting in deleterious side effects during use in cancer chemotherapy and limited experimental usefulness as mechanistic tools to study DNA replication. Towards development of targeted replication inh...

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Bibliographic Details
Main Authors: Anthony Schwacha, William L. Seibel, Jeffrey L. Brodsky, Sandlin Seguin, Matthew L. Bochman, Nicholas Simon
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-10-01
Series:Bioscience Reports
Subjects:
AAA+ ATPase
DNA replication
fluoroquinolone
helicase
minichromosome maintenance complex
Online Access:http://www.bioscirep.org/bsr/033/e072/bsr033e072.htm

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http://www.bioscirep.org/bsr/033/e072/bsr033e072.htm

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