Accelerated Deficits of Spatial Learning and Memory Resulting From Prenatal Inflammatory Insult Are Correlated With Abnormal Phosphorylation and Methylation of Histone 3 in CD-1 Mice

Accelerated Deficits of Spatial Learning and Memory Resulting From Prenatal Inflammatory Insult Are Correlated With Abnormal Phosphorylation and Methylation of Histone 3 in CD-1 Mice

Gestational infection causes various neurological deficits in offspring, such as age-related spatial learning and memory (SLM) decline. How inflammation causes age-related SLM dysfunction remains unknown. Previous research has indicated that histone modifications, such as phosphorylation of H3S10 (H...

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Bibliographic Details
Main Authors: Zi-Xing Wu, Lei Cao, Xue-Wei Li, Wei Jiang, Xue-Yan Li, Jing Xu, Fang Wang, Gui-Hai Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
histone
lipopolysaccharide
memory
methylation
phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00114/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00114/full

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